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The mother had a deficiency of neutral endopeptidase and probably had become immunized against the antigen at the time of or after an earlier miscarriage. (2002) described a case in which anti-neutral endopeptidase antibodies produced by a pregnant woman were transferred to a fetus, in which a severe form of membranous glomerulonephritis ( 614692) developed prenatally. These effects include diuresis, natriuresis, vasodilatation, and suppression of the renin-angiotensin-aldosterone system.ĭebiec et al. (1989) developed a specific enzyme inhibitor and reported that it had effects similar to those of low-dose ANF infusion.
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Atriopeptidase specifically degrades atrial natriuretic factor (ANF 108780) ( Stephenson and Kenny, 1987 Koehn et al., 1987). (1989) confirmed that CALLA is a functional neutral endopeptidase of the type that has previously been called enkephalinase.ĬALLA has also been called atriopeptidase. (2016) found expression of the MME gene in the myelin sheath of a human sural nerve, with lesser expression in the axon.īy cDNA transfection analysis, Shipp et al. (1989) determined that the CALLA gene encodes a 100-kD type II transmembrane glycoprotein. NEP cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.īarker et al. (1988) cloned a cDNA coding for CALLA and showed that the amino acid sequence deduced from the cDNA sequence is identical to that of human membrane-associated neutral endopeptidase (NEP EC 3.4.24.11), also known as enkephalinase. CALLA is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. CALLA is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. Common acute lymphocytic leukemia antigen (CALLA) is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL).